Labeling and animal study of fluorine-18-Levofloxacin
Abstract
Infection imaging is an important field in radionuclide imaging. But there are few reports about positron radionuclide labeled agents. To investigate a kind of specific infection imaging agent which can differentiate bacteria caused infection, we have radiosynthesized fluorine-18 labeled Levofloxacin (LVFX) for infection imaging. A typical Hamacher method was used to label LVFX. Radiochemistry purity was more than 98%, yield rate was about 40% and the pyretogen test result was negative. The labeling result showed that the labeling method was easy, procedure was simple and labeled agent was stable. The biodistribution and imaging of F-LVFX in animal model was also studied. 18 Both biodistribution and imaging result showed higher uptake of F-LVFX in infected tissues. The accumulation of 18 labeled agent in infected and normal tissue showed significant difference (P0.05). This labeled agent was mainly excreted through kidney and liver. It is suggested that fluorine-18 labeled LVFX is a potential infection imaging agent.
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