Pharmacokinetics of Levofloxacin in Hypothermic Beagle Dogs with Open Abdominal Wound by Artificial Seawater Immersion
Abstract
Objective To investigate pharmacokinetics of levofloxacin in beagle dogs under hypothermia with open abdominal wound by artificial seawater immersion and normal body temperature.Methods Twelve healthy beagle dogs were randomly divided into three groups(4 each):control group(group 1),hypothermia model group(group 2)and open abdominal wound and hypothermia model group(group 3).The beagle dogs in group 2 and group3 were immersed into artificial seawater for 90 min before being administered to prepare beagle dog hypothermia models.All the animals were administered with a single dose of levofloxacin(25 mg/kg) by infusion into the saphenous vein.Results The temperature of animals in group 1 predose and at 72 h postdose was normal(37.20±0.27)℃,but those in group 2 and group 3 were significantly decreased,the lowest values being(30.00±1.12)℃ and(29.8±1.03)℃ after immersion process,respectively.In comparison to those of group 1,t1/2β,Cmax,C12,C24 and AUC of animal in group 2 and group 3 were both significantly increased,respectively.ClS of group 2 and group 3 were both decreased compared with that of group 1.There was no significant difference in the main pharmacokinetic parameters between group 2 and group 3.Conclusion Hypothermia is an important factor that leads to difference in pharmacokinetics of levofloxacin in beagle dogs within 72 h while open abdominal wound had no effect.
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