(570) Unveiling Multifactorial Erectile Dysfunction in Klinefelter Syndrome: A Clinical Case
Abstract
Klinefelter syndrome (KS) is a common sex chromosome aneuploidy in men (47,XXY). Although rarely recognised in childhood and adolescence, a classical description is a patient with gynaecomastia, hypogonadism, and cardiovascular and metabolic abnormalities. Erectile dysfunction (ED), delayed ejaculation (DE) and decreased libido might be manifestations of male hypogonadism in KS, due to testicular dysfunction and androgen deficiency. Nevertheless, these symptoms might be attributable to other conditions, from vascular pathology, such as peripheral arterial disease (PAD), to psychosocial factors, like sexual performance anxiety. Understanding the overlapping mechanisms is essential to provide integrated and effective management, especially in primary care settings where coordination of multidisciplinary care is crucial.
To describe a case of ED in a patient with KS, highlighting the multifactorial etiology and the importance of a holistic and multidisciplinary management approach in primary care.
A descriptive case report of a 46-year-old male with KS followed in primary care. Clinical data were collected from endocrinology, urology, and vascular appointments between 2003 and 2025. Demographic, clinical, and laboratory information was reviewed, including endocrine and vascular assessments, testosterone replacement regimens, and responses to pharmacologic and psychosexual interventions. Observations focused on the evolution of sexual function, comorbidities, and treatment…
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