A Phase 1, Open-Label, Randomized, Cross-Over Study To Estimate The Pharmacokinetics Of PD 0332334 And Metformin When Administered Concurrently In Healthy Subjects
Abstract
1. To estimate the effects of multiple doses of PD 0332334 on the elimination of a single dose of metformin from the body
2. To estimate the effects of multiple doses of metformin on the elimination of a single dose of PD 0332334 from the body
3. To evaluate the safety and tolerability when PD 0332334 and metformin are administered at the same time.
Conditions: Generalized Anxiety Disorder.
Primary outcome: Metformin and PD 0332334 area under the curve (AUC) from time 0 to infinity (AUCinf); Metformin and PD 0332334 AUC from 0 to last quantifiable concentration (AUClast); Metformin and PD 0332334 half-life (t1/2); Metformin and PD 0332334 maximum plasma concentration.
Enrollment: 24 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 24 participants or records.
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