Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome
Abstract
OBJECTIVE: To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG).
DESIGN: Double-blind, randomized, placebo-controlled trial.
SETTING: University outpatient clinic.
PATIENT(S): The study cohort consisted of 50 obese women (body mass index [BMI] ≥ 27 kg/m(2)) and 60 nonobese patients (BMI <27 kg/m(2)), mean age was 27.7 ± 4.0 SD years.
INTERVENTION(S): Randomization to receive metformin or placebo for 3 months.
MAIN OUTCOME MEASURE(S): Serum levels of 8-OHdG before and after medical treatment.
RESULT(S): The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.
CONCLUSION(S): Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome.
CLINICAL TRIAL REGISTRATION NUMBER: NCT00994812.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 60 participants or records.
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