Epidemiology and Antimicrobial Resistance of Salmonella Isolates from Children in China (2017–2024) from a Multicenter ISPED Program
Abstract
Abstract Objective Salmonella and its increasing antimicrobial resistance (AMR) threaten public health. This study analyzed the epidemiology and AMR profiles of pediatric Salmonella in China to support rational antibiotic use. Method A multicenter retrospective study included 17540 Salmonella isolates from ISPED (2017–2024). Antimicrobial susceptibility was tested by disk diffusion and MIC, and analyzed with WHONET. Results Most isolates were from feces, peaking in children aged 1–3 years and during June–October. S. typhimurium and S. enteritidis were predominant. High resistance was observed to ampicillin (77.8%), ampicillin/sulbactam (39.3%), and trimethoprim/sulfamethoxazole (39.3%), while levofloxacin remained highly effective. Resistance differed by serotype, sample type and region, with S. enteritidis showing rising resistance to fluoroquinolones and cephalosporins. Conclusion Treatment should be individualized according to Salmonella serotype, regional epidemiological characteristics and antimicrobial susceptibility. Continuous national antimicrobial resistance surveillance is vital to improve antibiotic stewardship and public health interventions. Based on the multicenter ISPED program, this study clarified the epidemiological features and antimicrobial resistance of Salmonella isolates among Chinese children from 2017 to 2024. The findings support targeted public health planning, rational antibiotic use in pediatrics, strengthened Salmonella surveillance, and policy…
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