Averting Complications of Proton Pump Inhibitor Therapy by Effervescent Calcium Magnesium Citrate

ClinicalTrials.gov · TERMINATED, 2021

62 participants

Abstract

Proton pump inhibitors (PPIs) are widely used for the control of gastric ulcer-gastritis, erosive esophagitis (gastroesophageal reflux disease), peptic ulcer disease (duodenal ulcer), and heartburn. Despite their efficacy, their use has been implicated in possibly causing fragility fractures (osteoporosis), hypomagnesemia (magnesium deficiency) and increased risk of chronic kidney disease (CKD). The current trial represents the investigators' ongoing effort to discern whether these complications could be averted by effervescent calcium magnesium citrate (EffCaMgCit).

Conditions: Osteoporosis, Hypomagnesemia.

Primary outcome: Change From Baseline in Bone Mineral Density (BMD) T-Score at 2 Years; Change From Baseline in Bone Mineral Density (BMD) Z-Score at 2 Years; Change From Baseline in the Fractional Excretion of Magnesium (FEMg) at 2 Years; Change From Baseline in Free Muscle Magnesium at 2 Years; Change From Baseline in Endogenous Creatinine Clearance at 2 Years.

Enrollment: 62 participants.

How strong is the evidence?

Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 62 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

• ClinicalTrials.gov
• Publisher page

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