Serum 25-hydroxyvitamin D levels in children with distal radius torus fractures: A case-control analysis
Abstract
Background: Vitamin D influences bone mineralization, yet its relationship with distal radius torus fractures in children is uncertain. This study aims to investigate the relationship between serum Vitamin D levels and distal radial torus fracture.
Methods: We compared serum 25-hydroxyvitamin D (25[OH]D) levels between children with radiographically confirmed isolated distal radius torus fractures (n=236) and laboratory-tested pediatric outpatient controls (n=505). Controls underwent serum 25(OH) D testing during routine pediatric outpatient health evaluations and were not selected because of fracture, bone pain, suspected metabolic bone disease, or delayed fracture healing. In the fracture cohort, 25(OH)D was measured at the 3rd week after injury dur-ing outpatient follow-up. Group comparisons were performed using the Mann-Whitney U and Chi-square tests. Multivariable logistic regression assessed associations with age and sex. An exploratory subgroup analysis was additionally performed.
Results: Median 25(OH)D was 23.0 (interquartile range [IQR] 16.8-30.3) ng/mL in the fracture patients versus 18.4 (IQR=13.1-26.6) ng/mL in controls (p<0.001). Vitamin D deficiency (<20 ng/mL) occurred of the fracture group and 55.6% of the control group, respectively. After adjustment, 25(OH)D was not independently associated with torus fracture (adjusted OR/10 ng/mL 1.08, 95% CI=0.95-1.23; p=0.262), whereas male sex strongly predicted torus fracture (adjusted OR=3.35, 95% CI=2.41-4.66;…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 505 participants or records.
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