25-Hydroxyvitamin D Levels, Free Serum Calcium, Glomerular Filtration Rate, Albumin, and Femoral Fracture Elderly Patient Mortality
Abstract
Introduction: Proximal femoral fractures (PFFs) in older adults carry a high risk of morbidity, mortality, and disability. Although vitamin D deficiency has been associated with increased fracture incidence and poor outcomes, its precise role in hospitalization length, mortality, and long-term recovery remains unclear. Understanding how vitamin D levels interact with other factors, such as renal function and albumin status, could improve patient management strategies. Methods: We conducted a prospective cohort study of 760 patients aged 65 years and older admitted with femoral fractures between November 2022 and October 2024. Serum 25(OH)D levels, corrected calcium, and glomerular filtration rate (GFR) were assessed at admission. Vitamin D status was categorized as deficient (30 ng/mL). Albumin levels and GFR were also evaluated. Results: When analyzed categorically, vitamin D classification did not markedly predict short-term outcomes, including immediate postoperative mortality or length of hospital stay. However, vitamin D as a continuous variable was modestly associated with shorter hospital stays. By contrast, lower GFR was strongly linked to longer hospitalization and increased in-hospital mortality. Albumin levels were not markedly related to survival. Notably, over a 2-year follow-up, vitamin D status emerged as an important predictor of long-term survival. Conclusion: Although vitamin D status alone may not influence immediate recovery, maintaining adequate levels…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 760 participants or records.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.