A systematic review and meta-analysis of the global prevalence of fluoroquinolone resistant Morganella morganii clinical isolates
Abstract
Morganella morganii is an opportunistic pathogen that infects a variety of tissues. The increasing resistance of M. morganii to fluoroquinolones is a global public health concern. Hence, in this systematic review and meta-analysis, we aimed to determine the prevalence of fluoroquinolone resistance in M. morganii clinical isolates. We conducted a comprehensive search of the PubMed, Embase, ScienceDirect, and Scopus databases up to July 10, 2024, to identify studies on fluoroquinolone resistance in M. morganii. Studies that encompassed clinical isolates with fluoroquinolone susceptibility data were included. The prevalence of resistance was determined using a random-effects model, and heterogeneity was assessed using I2 statistics. Subgroup analyses were performed based on geographic region, study period, antibiotic susceptibility testing method, sample size, and study quality. Publication bias was evaluated using Begg's funnel plots and Egger's test. A total of 54 studies met the inclusion criteria, encompassing 45,440 clinical isolates. The pooled global prevalence of fluoroquinolone resistance in M. morganii was 21% (95% CI [16, 27]), with significant heterogeneity (I2 = 99.48%, p < 0.01). The resistance rate varied by region, with the highest rates observed in West Asia (62%) and Africa (55%) and the lowest in Australia (4%). The resistance rate also differed according to the type of fluoroquinolone, with the highest resistance recorded against the earlier-generation…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.