8224 Vitamin D Supplementation for Healthy Elderly People and the Incidence of Fracture: A Systematic Review and Meta-Analysis
Abstract
Abstract Disclosure: M.D. de Souza: None. R.L. Moraes Dantas: None. V.L. Duraes: None. G. Renganathan: None. T.B. Mendes: None. Background: The impact of vitamin D supplementation on the incidence of fracture in healthy elderly individuals remains uncertain. Objectives: We performed a systematic review and meta-analysis of studies investigating the incidence of fracture in healthy elderly patients with supplementation of vitamin D at doses exceeding 800 IU per day in comparison to placebo. Methods: We systematically searched PubMed, Embase and Cochrane Central Register of Controlled Trials in November 2023 with the main following search terms: ‘Vitamin D’, ‘supplementation’, ‘elderly’, ‘fracture’ and ‘randomized trial’. The initial search revealed 2,160 articles that were screened and assessed according to inclusion and exclusion criteria. Risk ratio (RR) and Hazard ratio (HR) with 95% confidence intervals were used to compare treatment effects for categorical endpoints. Heterogeneity was evaluated with Cochran Q test and I2 statistics; p values inferior to 0.10 and I2>25% were considered significant for heterogeneity. Results: A total of seven randomized controlled trials with 71,899 patients were included, of whom 36,822 (51.2%) were women. A total of 25,916 (78.2%) participants received a daily dose of vitamin D higher than 1,500 UI. The incidence of total fractures was not significantly different between participants who received vitamin D or placebo (RR 1.01; 95% CI…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 71,899 participants or records.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.