Letter to the Editor regarding “The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis”
Abstract
Dear Editor: We read with great interest the meta-analysis by Wang et al [1]. entitled “The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis.” We congratulate the authors for publishing their study in this journal. Yet upon the review of this article, there are serious issues that nullify the conclusions. We seek certain clarifications from the authors. First, the authors extensively searched the published literature through electronic databases (PubMed and Embase) and manually retrieved the references of the included studies, but these databases seemed to be not enough to retrieve all the eligible studies. Alternatively, other databases do exist, such as Cochrane Library, NLM Gateway, and BIOSIS previews as well as unpublished data like grey literature, which may contribute to get a more comprehensive collection of eligible studies. Secondly, about the adaptation of systematic review guidelines and registrations, there have been systematic review and meta-analysis protocol registration established that help to maintain a level of homogeneity and quality across all meta-analyses and systematic reviews being conducted. The meta-analysis was performed following the guideline of PRISMA, but the pre-defined protocol was not registered in any platform, such as the Cochrane Library and PROSPERO [2, 3]. Not only do the registration provides transparency in the review, but also improves the quality of conduct of the review and its subsequent…
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