Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review
Abstract
Introduction: Gastrointestinal surgery can result in short-term (in hospital) complications such as infections, post-operative ileus and poor wound healing and longer-term (post-discharge) complications such as intestinal failure, malnutrition and loss of bone mass. These complications can severely impact the patient and increase healthcare costs. Impaired immunity, excessive inflammation and oxidative stress can contribute to postoperative complications and poor outcome. Many micronutrients support immunity and help to control inflammation and oxidative stress. Therefore, providing micronutrients could mitigate poor outcome from surgery. The aim of this systematic review was to collate findings from randomized controlled trials (RCTs) of micronutrients provided to adult patients undergoing, or who had undergone, gastrointestinal surgery.
Methods: Searches were conducted in Medline and CINHAL; only literature from 2014 onwards was searched.
Results: A total of 12 articles reporting data from 11 RCTs were included. These trials studied vitamin D alone (administered orally) or combinations of different micronutrients (administered orally, intravenously or in wound dressings). Six trials started the intervention following discharge from hospital. Six trials had a low risk of bias overall, while five had some concerns. Two trials found that vitamin D decreased the loss of bone density in those who had undergone bariatric surgery, but two other trials did not find this; vitamin D…
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