Vitamin D Supplementation Dose as The Prevention of Fragility Fracture In Chronic Kidney Disease Patient: A Systematic Review
Abstract
CKD affects more than 10% of the global population. It can cause osteoporosis and increase the risk of fractures, especially as CKD becomes more serious. In CKD, mineral and bone disorders (CKD-MBD) cause abnormalities in how the body processes vitamin D, calcium, phosphorus, or parathyroid hormone (PTH). It can also affect bone strength and cause calcium build-up in the soft tissues. Treatment usually starts with correcting the chemical abnormalities that occur in the body due to CKD-MBD before focusing on osteoporosis and fractures. A study review spanning 2010 to 2023 investigated optimal vitamin D supplementation doses in CKD patients, indicating varied outcomes influenced by factors like dosage, duration, and population characteristics. Doses ranged from 800 to 8,000 IU/day of cholecalciferol, with recommendations contingent on serum 25(OH)D levels.
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.