Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial
Abstract
BACKGROUND: Osteoporosis is often responsible for bone fragility and increased fracture risk due to the micro-architectural deterioration of bone tissue. In addition to nutritional supplements, exercise is considered an adjunct factor in safeguarding bone health. This study aimed to investigate the effects of 16-week high-intensity interval training (HIIT) and vitamin D supplementation on bone mineral density (BMD) in women with osteoporosis.
TRIAL DESIGN: This study used a four-arm pretest-posttest experimental randomized controlled design.
METHODS: One hundred twenty sedentary women aged (30-50 years), diagnosed with osteoporosis were recruited in this study. Patients were randomly classified into four groups with 30 patients in each group: control group (normal daily activities), exercise group (HIIT-exercise for 16 weeks), Vitamin D group (vitamin D 800IU/ day for 16 weeks), and concurrent group (HIIT exercise plus vitamin D for 16 weeks). Anthropometric measurements, BMD, and serum levels of vitamin 25-(OH) D, Osteocalcin, s-BAP, and calcium were estimated in all participants before and after exercise training.
RESULTS: Serum samples revealed that bone resorption markers, osteocalcin, total calcium, s-BAP, and vitamin 25(OH) D significantly improved in all groups; there was greater improvement in the HIIT training-vitamin D group than in the HIIT training, vitamin D, and control groups. Furthermore, the HIIT training-vitamin D group showed improvements in hip (right and…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 30 participants or records.
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