Comparative study on the efficacy of menadione, zoledronic acid, and calcitriol in combination with PKP for the treatment of osteoporotic vertebral compression fractures in extremely elderly patients
Abstract
This study compares the efficacy and safety of menadione and zoledronic acid, both used in conjunction with calcitriol, in patients with osteoporotic vertebral compression fractures following percutaneous kyphoplasty (PKP) in an extremely elderly population. Patients with osteoporotic vertebral compression fractures (OVCF) were assigned into 4 groups. The basic treatment group received PKP and calcitriol for osteoporosis treatment. Experimental group 1 received menadione capsules in addition to the control treatment; experimental group 2 received zoledronic acid; experimental group 3 received both menadione soft capsules and zoledronic acid. The outcomes were assessed at 3, 6, and 12 months postoperatively, measuring visual analog scale (VAS) scores, Oswestry disability index (ODI), bone mineral density, anterior vertebral height ratio, correction of Cobb angle, inflammatory markers, biochemical markers of bone turnover, risk of refracture, and adverse drug reactions. At 3, 6, and 12 months postoperatively, both VAS and ODI scores in experimental groups 1, 2, and 3 were significantly lower than baseline and the basic treatment group. However, group 3 showed significantly lower scores than both groups 1 and 2 (all P .05). In extremely elderly patients with osteoporotic vertebral compression fractures, the combination of calcitriol with menadione soft capsules and zoledronic acid post-PKP significantly improves bone mineral density, promotes new bone formation, and effectively…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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