Anti-resorptive and anabolic therapies improve Falls Risk Assessment Score (FRAS) in postmenopausal women with type 2 diabetes mellitus
Abstract
UNLABELLED: Zoledronate, denosumab and teriparatide improve Falls Risk Assessment Score (FRAS) and reduce the number of participants experiencing falls over the last 12 months when administered over a period of 72 weeks to postmenopausal women with type 2 diabetes mellitus at a high risk of fragility fractures.
PURPOSE: Type 2 diabetes mellitus (T2D) increases the risk of falls, which also exacerbates the risk of fragility fractures. We aimed at exploring the effects of anti-osteoporotic therapies (zoledronate, denosumab or teriparatide) on the risk of falls in postmenopausal women with T2D.
METHODS: We performed an exploratory analysis of a randomized clinical pilot trial primarily designed to compare the efficacy of zoledronate, denosumab, or teriparatide in T2D (CTRI/2022/02/039978). Postmenopausal women (≥ 50 years) with T2D and high risk of fragility fractures were randomized to receive zoledronate (5 mg annually), denosumab (60 mg bi-annually), teriparatide (20 mcg daily) or only standard of care (calcium and cholecalciferol) for 72 weeks. The risk of falls was assessed using FRAS (Falls Risk Assessment Score) questionnaire at baseline and 72 weeks.
RESULTS: 129 postmenopausal women were randomized to one of the four treatment arms (mean age 64.2 ± 6.7 years). The baseline characteristics including FRAS were matched between four arms. At 72 weeks, all three interventions led to a significant reduction in FRAS (p = 0.002 for teriparatide, p = 0.004 for zoledronate, p =…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 129 participants or records.
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