OR13-6 Hyperparathyroidism and Abdominal Aortic Calcification in Older African American Women: PODA Trial
Abstract
Abstract Background: Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment (VFA) images have shown to be independently associated with increased cardiovascular risk and mortality. Vitamin D deficiency and toxicity have also been linked with vascular calcification. Objective: The objective of this study is to determine the natural progression of AAC in older African American (AA) women. We also wanted to evaluate the relationship between bone mineral markers and AAC. Methods: The study of relationship of Physical performance, Osteoporosis prevention with Vitamin D in older African Americans (PODA) is a randomized, double-blind, placebo-controlled 3-year trial examining the effect of vitamin D on bone loss and physical performance in 260 healthy AA women with mean age of 68.2 (65.4-72.5). Serum 25(OH)D levels were maintained above 75 nmol/l in the active group. We studied VFA images and assessed AAC using the Kauppila score(1). The scores were obtained separately for the anterior and posterior walls of L1-4 vertebrae, resulting in a range from 0 to 6 at each vertebral level and 0 to 24 for the total score. We used the antero-posterior severity score (AAC24) to report composite calcification scores and prospectively collected data annually for the PODA study participants over the course of 3 years. AAC24 cut off score of =>5 has shown to be associated with higher (2.4fold) cardiovascular mortality. Results: There were 14.7%(16/109) subjects with…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 260 participants or records.
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