Dental caries related primary hypertension in children and adolescents. Cross-sectional study
Abstract
BACKGROUND
Hypertension is a growing clinical problem in pediatric population. Also the cause of hypertension is usually unknown it may result from systemic inflammation related to tooth decay.
AIM
To estimate the potential association in cross-sectional study between tooth decay and hypertension in children and adolescents.
PATIENTS AND METHODS
Study group - 65 children diagnosed with primary arterial hypertension, control subjects - 44 normotensive children. Blood pressure, dental examination, measurement of salivary cortisol, alpha-amylase, secretory IgA and lysozyme concentrations were performed in all of the children.
RESULTS
Hyper- and normotensive children had similar peripheral blood morphology and serum biochemical parameters, except of uric acid concentration, which was significantly higher in the study group (p=0.047). Salivary evening concentrations of cortisol and alpha-amylase were significantly higher in hypertensive children (p=0.002 and p=0.004 respectively). Although 24-hour systolic blood pressure (SBP), including daytime and nighttime SBP, correlated with "decay", "microalbuminuria", "BMI" and "glomerular-filtration-rate" (r>0.75, r>0.7, r<0.68 and r<0.43 respectively), in multivariate analysis only "decay" was associated with hypertension both in children and adolescents (p<0.0001).
CONCLUSION
Tooth decay in children/adolescents might be regarded as a potent trigger factor of hypertension in individuals in whom all other causes of secondary arterial…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 65 participants or records.
Read the paper
Related studies
- Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature
- Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study
- Pubertal Recalibration of Cortisol Reactivity Following Early Life Stress: A Cross-Sectional Analysis
- High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study
- Effects of remote virtual work environment during COVID-19 pandemic on technostress among Menoufia University Staff, Egypt: a cross-sectional study
- Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes–a cross-sectional study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.