Thoracic paravertebral block versus local infiltration anesthesia for percutaneous kyphoplasty to treat osteoporotic vertebral compression fractures combined with intercostal neuralgia: a randomized controlled trial
Abstract
Background: Percutaneous kyphoplasty (PKP) is an effective treatment for osteoporotic vertebral compression fractures (OVCFs) and provides effective pain relief; however, its efficacy is questionable in patients with thoracic OVCFs combined with intercostal neuralgia (IN). This study aims to compare the efficacy and safety of thoracic paravertebral nerve block (TPVB) and local infiltration (LI) anesthesia for PKP to treat thoracic OVCFs combined with IN.
Methods: Patients with OVCFs combined with IN scheduled to undergo PKP between January 2021 and June 2022 were randomized into the following groups: TPVB and LI. Intraoperative visual analog scale (VAS) score, patients' anesthesia satisfaction (PAS) score, mean arterial pressure (MAP), and heart rate (HR) were recorded. Follow-up consultations were scheduled at 1 day, 1 month, 3 months, and 6 months postoperatively, recording the demographic characteristics, including surgical information, and complications observed in both groups. The clinical evaluation parameters included the VAS score, Oswestry Disability Index (ODI), and Short Form (SF)-36 score. Radiological evaluation parameters included the anterior vertebral body height ratio (AVBHR) and Cobb's angle of the injured vertebra.
Results: Sixty patients were enrolled (30 in each group), with similar clinical and demographic characteristics. The mean intraoperative VAS scores from time points T1 to T5 were significantly lower in the TPVB group [2 (1-2), 3 (2-3), 3 (3-4),…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.