Clinical features of osteoporosis in patients with type 1 and type 2 diabetes in Türkiye: A nationwide study
Abstract
This nationwide study assessed clinical features of osteoporosis in Turkish adults with diabetes. Osteoporosis prevalence was 9.36% in type 1 diabetes and 19.13% in type 2 diabetes, with higher rates in women and older individuals. Although overall fracture prevalence was low, fractures were markedly more frequent in patients with osteoporosis. Despite the high burden, most patients did not receive osteoporosis therapy, and age, female sex, and vascular complications were independently associated with osteoporosis.
Aim: Fragility fractures related to diabetes are increasing worldwide with rising life expectancy. We aimed to investigate the prevalence of osteoporosis and its associated factors in a large nationwide cohort of adults with type 1 (T1DM) and type 2 diabetes (T2DM) in Türkiye.
Methods: Using Turkish Ministry of Health electronic health records (2015-2021), adults with T1DM and T2DM were identified and classified according to the presence or absence of osteoporosis. Demographics, comorbidities, diabetes-related complications, fracture diagnoses, and laboratory parameters were analyzed. Factors independently associated with osteoporosis were evaluated using multivariable logistic regression.
Results: The cohort included 76,742 individuals with T1DM (mean age 44.3 ± 19.1 years; 45.8% women) and 7,006,910 with T2DM (mean age 59.1 ± 13.4 years; 60.2% women). Overall osteoporosis prevalence was 19.03% and was 9.3% in T1DM and 19.1% in T2DM. Osteoporosis was more…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 76,742 participants or records.
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