Retrospective Analysis on the Effect of Vitamin D Intake and Supplementation on Bone Mineral Density in Pediatric Leukemia Patients who underwent Allogeneic Bone Marrow Transplantation
Abstract
Children treated for leukemia with bone marrow transplant (BMT) are exposed to multiple risk factors that have been shown to have direct or secondary effects on vitamin D serum levels and subsequently, bone mineral density (BMD). Vitamin D insufficiency/deficiency has been associated with low bone mass and increased fracture rates in both adult and pediatric BMT recipients. The influence that dietary and supplemental vitamin D intake has on reducing BMD deficits in this specific patient population remains unclear. Our group retrospectively analyzed electronic medical record (EMR) and hard copy data from a population of leukemia survivors who underwent BMT at the UCSF Benioff Children's Hospital, Oakland, over the span of three years post transplantation. Vitamin D intake and serum levels in addition to other dietary, medication, and clinical factors that may have impacted long‐term bone health in this population were analyzed. Preliminary results show that prior to transplantation mean total vitamin D intake did not meet the DRI of 15 mcg/day (12.3 ± 3.2) but was satisfied post BMT, largely due to supplement intake. The total intake of vitamin D greatly increased over time but this observation was not found to be significant (p=0.077). Mean serum vitamin D levels also increased over time, although this was not found to be significant (p=0.187). Spine BMD, Z‐scores and whole body BMD Z‐scores did not significantly change over time, however, whole body BMD did significantly…
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