Correlation between vitamin D level and FRAX score in chronic kidney disease patient on maintenance hemodialysis
Abstract
Background: Vitamin D (Vit-D) deficiency is common in CKD on hemodialysis patients. Vitamin D deficiency can cause decreased bone density, increasing osteoporosis and fracture risk. The World Health Organization has developed a new fracture risk assessment tool (FRAX score) that has become increasingly popular in osteoporosis diagnostics and risk of fracture assessment in many countries. This study evaluates the correlation between vitamin D level and FRAX score in end-stage renal disease (ESRD) patients on hemodialysis.
Method: A cross sectional study was conducted on 68 CKD patients on routine hemodialysis in Dr.Soetomo General Hospital , Surabaya, in 2023. Sample taken through consecutive sampling. Calculation of FRAX score including age, gender, weight, height, history of fracture, parent's hip fracture status, smoking status, use of glucocorticoids, history of rheumatoid arthritis, secondary osteoporosis, alcohol, and BMD. A blood vein sample was taken to measure the serum vitamin D levels (25[OH]D) using a Human Vitamin D ELISA examination. Pearson correlation analysis was done using SPSS version 25 for Windows.
Results: The mean age of the study subjects was 51.24±10.50 years old, with most of the study subjects being female (61.8%). The mean serum vitamin D levels (25[OH]D) level was 18.82±8.94 ng/mL. We obtained two risk fractures from the FRAX score calculation, risk for hip fracture and risk of major osteoporosis. The mean risk for hip fracture was 1.52±1.22%,…
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