Correlation of vitamin D levels and lipid profile in coronary artery disease

Aaron Neville Edwin R, Y. C., Aruna Maria Bachmann

Global Journal For Research Analysis, 2025

50 participants

Abstract

Background: Vitamin D deciency is increasingly implicated in cardiovascular risk, yet its association

with coronary artery disease (CAD) and lipid prole remains ambiguous. This study aims to assess the

relationship between serum vitamin D levels, lipid prole, and the angiographic pattern of CAD. Methods: This cross-sectional

study was conducted over 18 months among 50 patients undergoing coronary angiography at Kempegowda Institute of

Medical Sciences, Bangalore. Serum vitamin D and lipid parameters (TC, HDL, LDL, VLDL, TG) were measured. Data were

analyzed using ANOVA, Pearson correlation, ROC curves, and Fisher's exact test. Results: The mean age was 60 years; 70%

were male. Vitamin D deciency was present in 64% of patients. Signicant associations were noted between low vitamin D

levels and triple vessel disease. HDL was signicantly lower in all CAD subgroups compared to normals (P<0.001). LDL and

VLDL were signicantly elevated in triple vessel disease (P<0.001). ROC analysis showed excellent predictive ability of LDL

(AUC 0.98), VLDL (AUC 1.00), and HDL (AUC 0.94) for CAD severity. Conclusion: Lower vitamin D levels and dyslipidemia

(especially low HDL and high LDL/VLDL) are signicantly associated with CAD severity. These ndings suggest a potential role

for vitamin D status in cardiovascular risk stratication.

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 50 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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