Hyponatremia independent of osteoporosis is associated with fracture occurrence
Abstract
BACKGROUND AND OBJECTIVES: Mild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture. A retrospective study was conducted to quantify the association of hyponatremia with fracture occurrence and to examine whether this relationship is independent of osteoporosis.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA) between September 1, 2006 and April 11, 2007 and who had available laboratory data. Self reported fracture occurrence was confirmed by radiology report or attendance at a fracture clinic. The significance and independence of the association of hyponatremia with fracture was quantified using logistic regression.
RESULTS: The mean (SD) serum sodium ([Na(+)]) was 140.6 (3.0) mmol/L; 59 (4.2%) had [Na(+)] or= 135 mmol/L remained significantly and independently associated with fracture occurrence (P < 0.01).
CONCLUSIONS: Mild hyponatremia may be a readily identifiable and potentially modifiable risk factor for fracture.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 1,408 participants or records.
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