Impact of Vitamin D Deficiency on Short- and Long-Term Mortality in Patients Receiving Hip Fracture Surgery Under General Anesthesia: A Matched Cohort Study
Abstract
BACKGROUND
Although vitamin D deficiency (VDD) is common in patients who have hip fractures, the relationship between VDD and mortality risk remains unclear.
METHODS
Using a network database (2010 to 2023), we conducted a matched cohort study of adult patients undergoing hip fracture surgery under general anesthesia. Patients were stratified according to preoperative 25-hydroxyvitamin D levels into VDD (≤ 20 ng/mL) and control groups (≥ 30 ng/mL). After 1:1 propensity score matching, 4,736 pairs were analyzed. The primary outcome was 12-month all-cause mortality. Secondary outcomes included 30- and 90-day all-cause mortality.
RESULTS
The 12-month mortality rate was significantly higher in the VDD group than in the control group (13.6 versus 11.6%, hazard ratio [HR]: 1.23, 95% confidence interval [CI]: 1.09 to 1.37, P = 0.0005). Similar patterns were observed at 30 days (3.4 versus 2.3%, HR: 1.52, P = 0.0007) and 90 days (7.1 versus 5.2%, HR: 1.41, P 65 years) and sex revealed a consistent association between VDD and mortality at 12 months. Vitamin D insufficiency (20 to 30 ng/mL) showed no significant association with increased mortality compared to the control group. Among patients who had VDD, malnutrition, neoplasms, diabetes mellitus, and heart disease have been identified as risk factors for 12-month mortality.
CONCLUSIONS
Preoperative VDD was significantly associated with increased mortality risk after hip fracture surgery, with particularly pronounced effects in the…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.