The Association of SGLT2i vs DPP4i on Fracture: A Cohort Study in Veterans with Diabetes
Abstract
Highlights • Diabetes is known to increase the risk of metabolic bone disease and fractures.• It has been postulated that SGLT2i use alters calcium, phosphate and vitamin D balance and could impact bone mineral density.• Among high-risk 76,000 SGLT2i users, there was no increased risk of fracture associated with SGLT2i use.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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