Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses’ Health Study
Abstract
Key Points Question Are high intakes of vitamins B6 and B12 associated with an increased risk of hip fracture? Findings In a cohort study of 75 864 US postmenopausal women, 2304 had a hip fracture. A combined high intake of vitamins B6 and B12 was associated with an increased risk of hip fracture. Meaning These results add to the evidence suggesting that caution should be used in vitamin supplementation when there is no apparent deficiency.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 864 participants or records.
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