A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin
Abstract
Objective:To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection.Meth- ods:According to the requirements of Cochrane systematic review,a thorough literature search was performed among Chinese digital Hospital Library(www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).A meta analysis was per- formed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria.Results:The clinical effective rate of indige- nous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups( OR 1.42,95% CI 1.03～1.98,Z=2.11 P=0.03) have significant difference.Clinical cure rates、corresponding bacterial eradication rates and adverse reac- tion rates have no significant difference.Conclusions:Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin.
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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