Meta-analysis of drug resistance of Escherichia coli to antibiotics from 2000 to 2011
Abstract
OBJECTIVE To analyze the drug resistance of Escherichia coli(E.coli)to cephalosporins and quinolones in Chinese mainland from 2000to 2011and to explore the development tendency of bacterial drug resistance and the relevant control measures.METHODS The drug resistance data of E.coli to cefuroxime,ceftriaxone,levofloxacin and ciprofloxacin reported by Chinese journals from 2000to 2013were collected,and were summarized and statistically analyzed with Excel software through meta analysis method.RESULTS The drug resistance of E.coli to 4types of antibiotics presented an annually upward trend;it increased fast before 2008and kept high after 2008;the drug resistance rates of E.coli to levofloxacin and ciprofloxacin were higher than that to ceftriaxone(P 0.01)and cefuroxime(P0.05)before 2008,and got closer after 2008;its resistance to cefuroxime was higher than that to ceftriaxone(P0.05),and there was no significant difference between the drug resistance rates to ciprofloxacin and levofloxacin;the detection rate of extended spectrumβ-Lactamases(ESBLs)producing E.coli showed an annually upward trend(P0.01),and the drug resistance rate of ESBLs-producing E.coli was higher than that of non ESBLs-producing E.coli(P0.01);in Chinese mainland,the isolated E.coli in the east had the lowest total resistance rate to the 4types of antibiotics,and there was no significant difference between the drug resistance rates of the E.coliisolated from other regions.CONCLUSIONThe drug resistance rate of…
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