Optimal age for screening lumbar osteoporosis in celiac disease
Abstract
Osteoporosis is a common and important predictor of poor outcomes in celiac disease (CD), which puts many patients at risk of further fractures. Our objective was to evaluate the stratification of osteoporosis odds in CD patients based on their age, aiming to determine the optimal timing for initiating osteoporosis screening in this population.This cross-sectional study was performed on adult CD patients who were referred to the Celiac Clinic Center between 2015 and 2020. The exclusion criteria included individuals with endocrine disorders, corticosteroid use, smoking habit, post-menopausal women, and patients younger than 25 years old. Intestinal pathology, bone mineral density (BMD), TGA-IgA serum level, and serum vitamin D were assessed at the time of diagnosis. A total of 199 CD patients, who underwent lumbar densitometry at the time of their diagnosis, were included in the study with a mean age of 39.14 ± 8.99 years old. Osteoporosis was observed in 23.6% patients, of whom 25.5% were men and 74.5% were women. The results revealed a notable disparity across the four age groups. After accounting for potential confounding factors in multivariate analysis in fully adjusted model, our findings demonstrated that individuals between the ages of 45 and 55 had 22% higher odds of developing lumbar osteoporosis (odds ratio, 1.22; 95% CI, 1.02-1.45) compared to those aged 25-35. Individuals with CD are at an increased risk of developing lumbar osteoporosis in middle age. Therefore,…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 199 participants or records.
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