Biochemical Pattern of Mineral Bone Disorder and Its Association with Fracture Risk Assessed by FRAX Tool in Chronic Kidney Disease Patients
Abstract
Background: Chronic kidney disease (CKD) is a major and increasing global health problem affecting 10–13% of the population, including a rising burden in Bangladesh. Progressive renal dysfunction leads to disturbances in mineral metabolism causing CKD–mineral bone disorder and increased fracture risk. This study aimed to evaluate the biochemical pattern of CKD–mineral bone disorder and its association with fracture risk assessed by the FRAX tool in CKD patients. Methods: This cross sectional study (May 2019–April 2020) was conducted in the Department of Nephrology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh, enrolling 161 CKD patients (≥18 years) to assess mineral bone disorder and fracture risk with FRAX (Indian model, without BMD). Demographic, clinical, and biochemical data were collected, CKD staged per KDIGO, serum analyzed by standard methods, and data processed in SPSS v22.0 (p < 0.05) with ethical approval. Results: Among 161 CKD patients, vitamin D abnormality (95.0%), elevated iPTH (88.2%), phosphate abnormality (68.9%), and calcium abnormality (53.4%) were highly prevalent. Most patients were in CKD stage G5 (47.8%), and diabetes mellitus was the leading cause of CKD (42.2%). No significant association was observed between CKD stage or most biochemical parameters and FRAX-based fracture risk. However, abnormal iPTH levels were significantly associated with increased major osteoporotic and hip fracture risk (p < 0.05). Conclusion:…
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.