Efficacy and Safety of Moxifloxacin vs. Levofloxacin for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review
Abstract
OBJECTIVE:To evaluate the efficacy and safety of moxifloxacin vs.levofloxacin for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) so as to provide a more optimal scheme in clinical application.METHEDS: The databases including CNK,WanFang Data and Chinese Biomedical Literature Database were electronically searched(searching time: from 2002 to 2013).The randomized controlled trials(RCTs) on moxifloxacin(trial group) vs.levofloxacin(control group) in the treatment of acute exacerbations of chronic obstructive pulmonary disease(COPD) meeting the inclusion criteria were included and meta-analysis was performed using RevMan 5.0 software.RESULTS: Seven RCTs involving 409 patients with COPD were included.The results of meta-analysis showed that trial group was significantly superior to control group in total effective rate [OR=2.79,95%CI(1.56-5.01),P=0.000 6];the bacterial clearance rate in trial group was also higher than in the control group [OR=2.27,95%CI(1.23-4.19),P=0.009].Of the total 409 patients,13 cases in the trial group vs.22 cases in control group presented with adverse reactions.CONCLUSION: Treatment of AECOPD with Moxifloxacin resulted in significantly higher effective rate and higher bacterial clearance rate yet less adverse drug reactions than with levofloxacin.Hence it is advisable to consider moxifloxacin as a substitute for levofloxacin in the treatment of AECOPD.
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 409 participants or records.
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