Effectiveness of levofloxacin for multidrug resistant pulmonary tuberculosis: a systematic review
Abstract
Objective: To systematically evaluate the effectiveness of levofloxacin in controlling multidrug resistant tuberculosis (MDR-TB). Methods: Literatures in databases such as Wanfang database、CNKI and Periodical database of the Chinese Medical Association from 2000 to 2012 were searched, sometimes with the aid of hand searching to collect randomized controlled trials on levofloxacin used to treat MDR-TB, in which their quality was evaluated by adopting the Jadad scale and meta-analysis was performed by RevMan 5.0 software. Results: A total of 26 RCTs involving 2 791 cases were included.The results of meta-analysis showed the efficacy of levofloxacin in the sputum negative conversion rate, the focus absorption and cavity closure rate was significantly better than that of pasiniazid, rifapentine, ethambutol and amikacin as compared with the placebo group. Conclusion: Levofloxacin for the treatment of MDR-TB is safe and effective. However, because of the limited number and low quality of literatures, it may need large sample and high quality of research to be further verified.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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