Throwing Fracture of the Humerus in an Adolescent Patient Exposed to Isotretinoin: A Case Report of Successful Nonoperative Management
Abstract
Throwing fractures of the humerus are uncommon and typically occur in deconditioned adults. When they occur in adolescents, investigation into potential secondary causes is paramount. Medication history may provide insight into potential secondary causes of humerus fracture and should be investigated. While it is unclear whether isotretinoin plays a clinically significant role in fracture risk in humans, it has been associated with alterations in bone metabolism and should remain a topic of further study. Nonoperative management with a functional brace continues to be a mainstay of treatment in the absence of surgical indications.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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