P-028 atypical femur fracture after denosumab treatment: a case report
Abstract
Abstract Introduction Osteoporosis is a metabolic bone disease characterized by decreased bone mineral density and deterioration of bone microarchitecture, leading to an increased risk of fractures. Antiresorptive drugs are the first choice for treatment. Atypical femoral fractures (AFF) are a rare complication that can occur after bisphosphonate or denosumab therapy, especially in patients at high risk for fracture. We present a case of atypical femur fracture that developed in the second year of denosumab treatment, which was initiated after bisphosphonate treatment in our clinic due to postmenopausal osteoporosis. Clinical Case A 76-year-old female patient was followed in our clinic postoperative hypothyroidism after bilateral total thyroidectomy caused by multinodular goiter and postmenopausal osteoporosis. Between 2014 and 2022, she was treated with bisphosphonates (oral alendronic acid/cholecalciferol and ibandronic acid, intravenous ibandronic acid) for postmenopausal osteoporosis. She was receiving replacement therapy due to vitamin D deficiency. The bone mineral density (BMD) measurements taken during her follow-ups are summarized in Table 1. Hemogram, kidney and liver function tests, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase values, as well as 24-hour urinary calcium levels, were within normal limits. Additionally, celiac autoantibodies, anterior pituitary hormones, and sedimentation rates were checked to rule out secondary osteoporosis due…
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