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Enhancement in Bone Density in Osteopenia with Polyherbo-mineral Formulations - A Case Report Using Quantitative Ultrasound (QUS)

Vd. Digambar G. Dipankar, Vd. Bhumika B Jain, K. More

International Journal of Drug Delivery Technology, 2026

Abstract

Background

Osteopenia represents a precursor stage to osteoporosis and is associated with an increased risk of fragility fractures, especially in

postmenopausal women and the elderly. The global burden of Osteopenia and Osteoporosis is steadily increasing with lifestyle factors

such as sedentary habits, poor dietary intake of calcium and vitamin D supplementation.

Case Presentation

A 39-year-old female presented with severe bone pain, hair fall, fatigue, and joint loosening. She was diagnosed with osteopenia,

confirmed by Quantitative Ultrasound (QUS) scan showing a T-score of –1.70 and a serum calcium level of 8.6 mg/dL. The patient was

managed with polyherbal and mineral formulations that included tablets, a decoction, dietary recommendations and mild exercises for

4 weeks. She was assessed at 15-day intervals.

Results

Over the course of treatment, she reported improvements in energy, reduced bone pain, decreased hair fall, and relief from fatigue and

joint discomfort. At the end of four weeks, her QUS T-score improved to –0.13, while her serum calcium levels increased to 9.0 mg/dL.

Conclusion

This case suggests that management by polyherbal formulations may have a positive role in improving bone mineral health in osteopenia

individuals, although further clinical studies are necessary to substantiate these findings.

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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