Biological therapy for osteoporosis - solving clinical problems - a case report
Abstract
Introduction. Elucidation of the pathogenetic mechanisms of osteoporosis has
led to the development of new and effective drugs from the group of
biological agents. Case report. In April 2018, a 64-year-old female patient
was presented to the hospital due to low back pain. She was diagnosed with
postmenopausal osteoporosis based on bone density scan score and a
compression fracture of the L1 vertebral body revealed by X-ray. She was
treated with a weekly bisphosphonate and supplementation with vitamin D and
calcium. After one year, monthly bisphosphonate was introduced in therapy
because of an inadequate response. In April 2020, the patient was treated
for COVID-19 according to protocol, and during the treatment, bisphosphonate
therapy was discontinued. After five months, she suffered a fracture of her
left forearm. Due to the persistence of low mineral bone density, which was
complicated by a new fracture, denosumab 60 mg subcutaneously once every six
months was initiated with additional vitamin D and calcium supplementation.
At six months follow-up, an increase in mineral bone density was verified,
and after 12 months, the dual-energy x-ray absorptiometry score was within
the osteopenia range. Laboratory findings showed a decrease in bone turnover
markers. Conclusion. One-year administration of denosumab led to a
significant increase in bone mineral density measured at the lumbar spine
and neck of the femur, as well as changes in the levels of biochemical
markers of bone…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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