Effect and Safety of Bronchoscopy Based on Imaging Evaluation in Patients With Acute Exacerbation of Bronchiectasis
Abstract
Objective: To evaluate the efficacy and safety of imaging-assisted bronchoscopic interventions in acute bronchiectasis exacerbations and analyze their effects on pulmonary function, inflammation, and quality of life for evidence-based clinical support.
Methods: A total of 80 inpatients with acute bronchiectasis exacerbations were randomized into a control group (n = 40), receiving conventional anti-infective and symptomatic treatment, and an intervention group (n = 40), receiving additional imaging-assisted bronchoscopic intervention. Pulmonary function, inflammatory markers (C-reactive protein [CRP], procalcitonin [PCT], and white blood cell count [WBC]), and St George's Respiratory Questionnaire (SGRQ) quality of life scores were assessed preintervention and at 1, 2, and 4 weeks. Adverse events (e.g., hemoptysis, pneumothorax, and infection spread) and overall effectiveness were recorded.
Results: No significant intergroup differences were observed in baseline characteristics, preintervention pulmonary function (forced expiratory volume in the first second [FEV1], forced vital capacity [FVC], and FEV1/FVC), inflammatory markers (CRP, PCT, and WBC), or SGRQ scores (p > 0.05). After 1, 2, and 4 weeks, the intervention group demonstrated significantly greater improvements: higher FEV1, lower CRP and PCT levels, and reduced SGRQ scores compared with the control group (p < 0.05). The generalized estimation equation (GEE) model revealed that the improvement magnitude in the…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 40 participants or records.
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