Linking the relationship between drug-induced osteoporosis and the gut microbiota
Abstract
Drug-induced osteoporosis is considered secondary osteoporosis caused by pharmacological drugs that can alter the diversity and function of the gut microbiota (GM), which in turn may be associated with the development or exacerbation of osteoporosis. This review uncovers the relationship between drug-induced osteoporosis and GM based on preclinical and clinical studies. In this context, we focused on secondary osteoporosis induced by glucocorticoids, aromatase inhibitors, proton pump inhibitors, antiretroviral drugs, antiepileptic drugs, antipsychotics, antidepressants, and subsequent alterations in the GM. Different pharmacological drugs can induce secondary osteoporosis through multiple mechanisms, and some of them exert similar mechanisms of their harmful effect on bone health, including decreased osteoblastogenesis, increased osteoclastogenesis, disturbances in calcium and vitamin D metabolism, alterations in hormone and cytokine levels. In addition, diverse drugs can significantly reshape gut microbial communities, often in a drug- and context-specific manner. However, the mechanisms linking individual drugs, GM, and bone health are still largely unresolved. There is little or no direct evidence that drug-induced GM alterations mediate changes in bone turnover, bone mineral density (BMD), or fracture risk for most of the drug classes mentioned. Observational and interventional clinical studies in this area are necessary to provide conclusive evidence of the association…
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.