Safety and efficacy of nemonoxacin versus levofloxacin in the treatment of community-acquired pneumonia: results of phase III, multicenter, randomized, double-blind, active-controlled, non-inferiority trial

Roman Sergeevich Kozlov, Andrey V. Dekhnich, А. А. Зайцев, R.Ya. Nilk, М.Yu. Samsonov, R-Pharm JSC, B. V. Berezhanskiy, R-Pharm JSC et al.

Clinical Microbiology and Antimicrobial Chemotherapy, 2018

Abstract

Objective. To evaluate the efficacy and safety of a step-down strategy from intravenous to oral nemonoxacin versus a step-down strategy from intravenous to oral levofloxacin in the treatment of patients with community-acquired pneumonia. Materials and Methods. This was a phase III randomized, controlled, double-blind, double-dummy, parallel groups (2 groups), multicenter trial to evaluate the efficacy and safety of intravenous and oral nemonoxacin at a daily dose of 500 mg versus levofloxacin (Tavanic®) at a daily dose of 500 mg in the treatment of adult patients with community-acquired pneumonia.

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