Baicalin alleviates uterine inflammaging and improves eggshell quality in aged laying hens
Abstract
Aging is a major contributor to the decline in egg quality, with uterine inflammaging playing a key role in this process. Implementing anti-aging strategies to prevent uterine inflammaging and sustain optimal eggshell quality is imperative. This study aimed to characterize age-related changes in the eggshells and uteri of hens at different laying stages and the regulatory effect of baicalin (BAI). Uterine inflammaging became progressively more evident with advancing hen age, as indicated by fibrosis of the lamina propria connective tissue, decreased height and width of primary uterine folds (P α) and interleukin-6 (IL-6), and decreased messenger RNA (mRNA) expression of the longevity gene sirtuin 1 (SIRT1) (P P in vivo, BAI treatment alleviated uterine inflammaging, mainly reflected in reduced secretion of the proinflammatory cytokines interleukin-1 beta (IL-1β), IL-6, and interleukin-8 (IL-8) and reduced expression of TNF-α, IL-1β, p53, and p21 (P P P In vitro, compared to uterine epithelial cells cultured with β-galactosidase, BAI pretreatment increased cell viability, decreased the positive staining rate of senescent cells, downregulated the relative expression of IL-6, IL-1β, TNF-α, p53, and p21, and increased SIRT1 mRNA levels (P < 0.05). Overall, uterine inflammaging was closely associated with age-related deterioration in eggshell quality, and BAI administration was associated with improved eggshell quality and reduced uterine inflammaging.
Read the paper
Related studies
- Effectiveness of Bisphosphonates and Denosumab on Risk of Vertebral Fractures in Prostate Cancer Patients Under Androgen Deprivation Therapies: A Real-World Prospective Study
- Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
- Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study
- Muscle strength and body composition are clinical indicators of osteoporosis
- Incidence of bone protection and associated fragility injuries in patients with proximal femur fractures
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.