Efficacy of collagen peptide supplementation on bone and muscle health: a meta-analysis
Abstract
Background: Collagen peptide supplements, especially when combined with vitamin D as well as calcium, are showing promise as a means of enhancing the condition of muscle and bone. This meta-analysis examined how collagen peptide intake affected muscular performance, bone turnover metrics, probability of fracture, and bone mineral density (BMD).
Objective: The primary goal of this meta-analysis was to investigate the influence of collagen peptide treatment on musculoskeletal indices, bone turnover indicators, and BMD. The interaction of collagen peptides with vitamin D and calcium was of special significance.
Methods: Randomized trials evaluating collagen peptide intake, either independently or in combination with calcium and vitamin D, were systematically reviewed and meta-analyzed. In order to synthesize effect sizes among trials, standardized mean differences (SMDs) using 95% confidence intervals were computed. The Cochran's Q analysis and the I2 measure were employed to determine variability.
Results: Studies revealed that supplementing with collagen peptide significantly increased BMD in the femoral neck and spine. Nonetheless, there was a significant amount of variation in BMD results across trials (I2 = 80.1%). Collagen had no noticeable variance (I2 = 0%) and enhanced bone turnover indicators (SMD 0.40-0.58) and muscle performance (SMD 0.60 [0.05, 1.15]). When collagen was paired with the nutrients vitamin D and calcium, positive synergies were noticed (SMDs…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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