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Ceftriaxone Versus Cefazolin Susceptibility as a Surrogate Marker for Cefpodoxime Susceptibility in Enterobacterales

Lambert KV, Demkowicz R, Murray A, Howard C, Slain D

Open forum infectious diseases, 2024

3 citations

Abstract

The Clinical and Laboratory Standards Institute stated that cefpodoxime susceptibility among Enterobacterales can be inferred from cefazolin, but this may overcall cefpodoxime resistance. We report a categorical agreement rate of 64% for cefazolin and 97% for ceftriaxone with cefpodoxime (P = .0001). Ceftriaxone appears to be a more useful cefpodoxime surrogate.

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Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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