Helicobacter pylori infection in children: an overview of global characteristics and the effectiveness of tailored therapy
Abstract
Introduction: No specific symptomatology or typical endoscopic features exist for children infected with Helicobacter pylori, except for nodular gastritis, which, when present, is highly predictive of the infection. Despite international guidelines, empiric antibiotic eradication remains common. This study compares the clinical and endoscopic features of infected and non-infected children and evaluates antimicrobial resistance and eradication rates between tailored and empirical treatments.
Methods: We retrospectively analyzed all children infected with H. pylori who were diagnosed by gastroscopy and histology over 3 years, matching them with H. pylori-negative controls. Infected children with known antibiotic susceptibility received tailored therapy, while others were treated empirically.
Results: Clinical and endoscopic features did not differ significantly between the groups, confirming that one cannot diagnose H. pylori infection based on these features. Chronic active and non-active gastritis were present in all the infected and non-infected children, respectively. Clarithromycin and metronidazole resistance were 46.2% (6/13) and 23.1% (3/13), respectively. Eradication was obtained in 100% of the patients who received susceptibility-directed therapy compared to 75% in those who received empiric therapy.
Discussion: We confirm that infected and non-infected children present with similar clinical and macroscopic features in gastroscopy and resistance to amoxicillin and…
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.