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Benefits of blue light-filtering intraocular lenses for subjective sleep quality: A systematic review and meta-analysis

Yao J, Jiang Z, Zhang H, Chen H, Li T, Yuan M

Medicine, 2025

1,007 participants

Abstract

Background: The increasing use of digital devices has raised concerns about the effects of blue light exposure on overall well-being. Blue light-filtering intraocular lenses (BF-IOLs) have been developed to mitigate these effects, particularly in cataract surgery. This systematic review and meta-analysis aimed to evaluate and compare the benefits of BF-IOLs and standard intraocular lenses (IOLs) on the subjective sleep quality of cataract patients.

Methods: Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Embase, and the Cochrane Library from inception to May 2024. Studies that compared BF-IOLs with standard IOLs in cataract patients were included. Risk of bias was assessed using the revised Cochrane Risk-of-Bias tool for randomized trials (RoB 2.0).

Results: A total of 8 studies, including 1007 patients, were analyzed. These studies showed variability in design and quality, with some exhibiting moderate-to-high risks of bias. The random-effects model indicated that BF-IOLs were associated with a slight, statistically nonsignificant improvement in subjective sleep quality in cataract patients, with limited clinical relevance compared with standard IOLs (4-12 months postimplantation), with a standardized mean difference of 0.10 (95% confidence interval [CI]: 0.00-0.21). However, no significant between-group difference was observed in the longer term (6-12…

How strong is the evidence?

Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,007 participants or records.

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