The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes
Abstract
Background and purpose: Melatonin supplementation has shown potential benefits in the management of diabetes in clinical trials; however, prior meta-analyses have not specifically focused on individuals with type 2 diabetes mellitus (T2DM). This study investigates the efficacy of melatonin supplementation in improving glycemic control among patients with T2DM by systematically reviewing and analyzing data from randomized controlled trials (RCTs).
Methods: A comprehensive literature search was conducted in PubMed, Cochrane Library, Scopus, Web of Science, and Embase from their inception to September 2024. RCTs evaluating the effects of melatonin supplementation in adults diagnosed with T2DM were included. The methodological quality of the studies was assessed using the Cochrane Risk of Bias Tool. Data were synthesized and analyzed using RevMan version 5.3.
Results: A total of nine RCTs were included in the meta-analysis (n=9). These studies collectively involved 427 participants. Melatonin supplementation was associated with a statistically significant reduction in glycated hemoglobin (HbA1c) levels compared to placebo [mean difference [MD]: -0.65; 95% CI: -1.28, -0.02; P = 0.04], However, no significant effect was observed on fasting plasma glucose (FPG) levels [mean difference: -6.40; 95% CI: -15.79, 2.99; P = 0.18].
Conclusion: This meta-analysis suggests that melatonin supplementation significantly reduces HbA1c levels in patients with type 2 diabetes mellitus compared to…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 427 participants or records.
Read the paper
Related studies
- A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Evaluating the Evidence Base of Melatonin, Light Exposure, Exercise, and Complementary and Alternative Medicine for Patients with Insomnia Disorder
- Use of Melatonin and/on Ramelteon for the Treatment of Insomnia in Older Adults: A Systematic Review and Meta-Analysis
- Influence of evening light exposure on polysomnographically assessed night-time sleep: A systematic review with meta-analysis
- Use of melatonin in children and adolescents with idiopathic chronic insomnia: a systematic review, meta-analysis, and clinical recommendation
- Significant potential of melatonin therapy in Parkinson’s disease – a meta-analysis of randomized controlled trials
- Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.