The Effects of Time-Restricted Eating in Women with Polyendocrine Metabolic Ovarian Syndrome: A Systematic Review and Meta-Analysis
Abstract
Background: Polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS), is a complex endocrine-metabolic disorder strongly associated with insulin resistance, hyperandrogenism, and obesity. Time-restricted eating (TRE) has emerged as a promising dietary strategy for improving metabolic health; however, evidence regarding its efficacy in women with PMOS remains limited. Objective: To systematically evaluate the effects of TRE on metabolic, hormonal, anthropometric, and adherence-related outcomes in women with PMOS. Methods: PubMed, Embase, Scopus, and Web of Science were systematically searched through 25 April 2026, for randomized controlled trials evaluating TRE interventions in women with PMOS. Random-effects meta-analyses were performed to pool mean differences (MD) with 95% confidence intervals for specific metabolic, hormonal, and anthropometric outcomes. Results: Four randomized controlled trials comprising 216 women with PMOS were included; three trials compared TRE with calorie restriction and one with ad libitum intake. Compared with control interventions, TRE significantly improved HOMA-IR (MD = -0.58, 95% CI: -0.87 to -0.30), QUICKI (MD = 0.08, 95% CI: 0.04 to 0.13), and HDL (MD = 1.97 mg/dL, 95% CI: 0.96 to 2.99). TRE was generally associated with high adherence across the included studies, with some trials reporting higher compliance than calorie restriction. Conclusions: Current evidence from four RCTs suggests that TRE…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 216 participants or records.
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