P-645 Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials
Abstract
Is there any available evidence on the effect of melatonin supplementation during controlled ovarian stimulation (COS) on assisted reproductive technology (ART) outcomes?
Melatonin supplementation improve oocyte maturation rate, and embryo quality, and clinical pregnancy rates in assisted reproduction.
Melatonin, a hormone synthesized mainly by the pineal gland and secreted during the night, plays a key role in regulating biological rhythms, such as inducing sleep. It also possesses antioxidant properties, potential anticarcinogenic effects, and a protective role against neurodegenerative diseases. Owing to its well-established antioxidant properties, melatonin supplementation has been posited as a valuable adjunct to in vitro fertilisation (IVF) protocols, given that oxidative stress is known to compromise treatment success. Furthermore, melatonin exerts a critical regulatory function within the antral follicle, directing steroidogenesis and modulating the mRNA expression of luteinising hormone (LH) and maturation-inducing hormone.
A systematic review and meta-analysis of randomised controlled trials (RCTs) was performed in accordance with the Cochrane Handbook and PRISMA guidelines. The search included studies from inception to August 2024. All eligible RCTs comparing melatonin supplementation versus no melatonin in infertile patients undergoing COS for ART were included.
For this, the PICO framework was applied: Population: patients undergoing ART; Intervention: melatonin…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 833 participants or records.
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