High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial
Abstract
Highlights • First double blind RCT of vitamin D therapy in mechanically ventilated patients.• Treatment with placebo, 250,000 IU or 500,000 IU enteral vitamin D3 was well tolerated.• Significant increase in plasma 25(OH)D from baseline to day 7.• Significant decrease in hospital length of stay for vitamin D3 treated subjects.• No change in plasma LL-37 according to treatment group.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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